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KMID : 0043320080310101325
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Archives of Pharmacal Research
2008 Volume.31 No. 10 p.1325 ~ p.1329
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A New Ferulic Acid Ester and Other Constituents from Dracocephalum peregrinum
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Tang Jian
Zhang Wei-Dong
Peng Cai-Yun
Li Hui Liang
Shen Yun-Heng
Jin Hui Zi
Zhao Chun-Chao
Dai Li-Min
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Abstract
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A new ferulic acid ester, 1’-methyl-2’-hydroxyethyl ferulate (1), together with methylcaffeate (2), 4- hydroxy cinnamic acid (3), ferulic acid (4), caffeic acid (5), diosmetin (6), luteolin (7), 5,3’,4’-trihydroxy- 3,7-dimethoxyflavone (8), eriodictyol (9), kaempferol (10), quercetin (11), acacetin-7-Oglcopyranoside (12), 4-(β-glucopyranosyloxy) benzoic acid (13), luteolin-7-O-(6’’-feruloyl) glucopyranoside (14), luteolin-7-O-glucopyranoside (15), kaempferide-3-O-rhamnopyranoside (16), quercitrin (17), kaempferol-3-O-glucopyranoside (18), prunasin (19), quercetin-7-O-glucopyranoside (20), quercetin-3-O-glucopyranoside (21), plantaginin (22), linarin (23), luteolin-7-O-rutinoside (24), and chlorogenic acid (25) were isolated from the aerial parts of Dacocephalum peregrinum. The structure of 1 was elucidated on the basis of spectroscopic and HR-ESI-MS analyses. In addition, compound 1 exhibited mild inhibitory effect on NO production in LPS-stimulated RAW264.7 cells.
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KEYWORD
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Dacocephalum peregrinum, Ferulic acid ester, 1’-Methyl-2’-hydroxyethyl ferulate, NO production
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